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Published on: August 25, 2017
The aging lung and chronic obstructive pulmonary disease: similarity and difference
1Department of Respiratory Medicine, CRD Research Institute, Juntendo University, Bunkyo-ku Hongo 2-9-8, Tokyo, Japan. yfukuchi@tea.ocn.ne.jp
Premature aging does not directly cause emphysema in elderly lungs. However, aging increases susceptibility to external factors like tobacco smoke, potentially leading to chronic obstructive pulmonary disease (COPD).
Area of Science:
- Gerontology
- Pulmonology
- Pathology
Background:
- Chronic obstructive pulmonary disease (COPD) prevalence increases with age.
- Age-related lung changes may heighten susceptibility to COPD pathogenesis.
- The hypothesis that lungs develop COPD in old age requires investigation.
Purpose of the Study:
- To investigate the role of premature aging in COPD development.
- To determine if aging itself causes emphysema or increases susceptibility to insults.
- To identify suitable animal models for studying age-related COPD.
Main Methods:
- Utilized senescence-accelerated mice (SAM), Klotho gene-depleted mice, and SMP-30 knockout mice.
- Examined structural and physiological lung changes in premature aging models.
- Exposed aged animal models to tobacco smoke to induce emphysema.
Main Results:
- Senile lung changes observed, characterized by lack of alveolar wall destruction, not emphysema.
- Tobacco smoke exposure induced emphysema in aged animal models.
- Premature aging enhanced susceptibility to emphysema induced by tobacco smoke.
Conclusions:
- Premature aging is not a direct cause of emphysema.
- Aging enhances lung susceptibility to extrinsic factors like tobacco smoke.
- Further research into the mechanisms of this enhanced susceptibility is crucial for advancing COPD management.
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