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Rising incidence of inflammatory bowel disease among children: a 12-year study
Hoda M Malaty1, Xiaolin Fan, Antone R Opekun
1Department of Medicine, Baylor College of Medicine, Houston, TX, USA. Hmalaty@bcm.tmc.edu
Insights
The incidence of pediatric inflammatory bowel disease (IBD) has doubled between 1991 and 2002, with Crohn disease (CD) showing a significant increase. These findings highlight the growing prevalence of IBD in children.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Inflammatory Bowel Disease Research
Background:
- Growing concerns regarding the increasing incidence of pediatric inflammatory bowel disease (IBD).
- Need to understand trends in IBD diagnosis among children.
Purpose of the Study:
- To investigate the trend in the incidence of pediatric inflammatory bowel disease (IBD).
- To analyze the changes in IBD diagnosis rates in children over time.
Main Methods:
- Retrospective cohort study of children diagnosed with IBD between 1991-2002.
- Diagnosis confirmed via clinical, radiological, endoscopic, and histological evaluations.
- Data collected from the IBD center at Texas Children's Hospital.
Main Results:
- The incidence of pediatric IBD doubled from 1.1 to 2.4 per 100,000 person-years between 1991 and 2002.
- Crohn disease (CD) incidence increased, while ulcerative colitis (UC) incidence remained stable.
- White children exhibited a higher IBD incidence rate compared to African Americans and Hispanics.
Conclusions:
- The study confirms a rising trend in pediatric IBD, predominantly driven by Crohn disease.
- These epidemiological shifts have significant implications for the diagnosis and management of IBD in pediatric populations.
- Understanding demographic variations in IBD incidence is crucial for targeted healthcare strategies.
Objective:
Data suggest an increase in the incidence of pediatric inflammatory bowel disease (IBD). We examined the trend of the incidence of IBD in children.
Patients And Methods:
A retrospective investigation was conducted on a cohort of children diagnosed with IBD between 1991 and 2002 who were registered in the IBD center at Texas Children's Hospital. The diagnosis of IBD was based on clinical, radiological, endoscopic, and histological examinations.
Results:
There were 272 children eligible for the analysis; 56% diagnosed with Crohn disease (CD), 22% with ulcerative colitis (UC), and 22% with indeterminate colitis. The male-to-female ratio was 1.2:1 in CD, 0.6:1 in UC, and 0.8:1 in indeterminate colitis. From 1991 to 2002, the incidence rate has doubled from 1.1/100,000/year (95% confidence interval [CI] 0.85-1.36) to 2.4/1001,000/year (95% CI 2.10-2.77). This trend was valid for CD but not for UC. Whites had higher incidence rate of IBD than African Americans or Hispanics: 4.15/100,000/year (95% CI 3.48-4.82) versus 1.83/100,000/year (95% CI 1.14-2.51), and 0.61/100,000/year (95% CI 0.33-0.89), respectively. African Americans were predominantly diagnosed with CD.
Conclusions:
The results demonstrate the rising incidence of IBD among children with evidence of more CD than UC. Recognition of these results will have important implications for diagnosis and management of IBD in children.
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