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Evaluation of safety for bilateral same-day intravitreal injections of antivascular endothelial growth factor therapy

Luiz H Lima1, Sandrine A Zweifel, Michael Engelbert

  • 1Vitreous, Retina, and Macula Consultants of New York, New York, New York 10022, USA.

Retina (Philadelphia, Pa.)
|November 26, 2009
PubMed

Insights

Bilateral same-day intravitreal injections of anti-VEGF drugs show low complication rates, similar to unilateral treatments. While rare, severe inflammation can occur unilaterally after bevacizumab injections.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Pharmacotherapy

Background:

  • Intravitreal injections of anti-VEGF agents are standard for retinal diseases.
  • Bilateral same-day injections offer convenience but require safety evaluation.

Observation:

  • A retrospective review analyzed 1,534 bilateral intravitreal injections (bevacizumab and ranibizumab) in 367 patients.
  • Complications included two cases of endophthalmitis and one of intraocular inflammation.
  • No retinal tears or detachments were observed.

Findings:

  • The incidence of endophthalmitis was 0.065% and intraocular inflammation was 0.033%.
  • Complication rates appear comparable to unilateral injections.
  • Severe inflammation occurred unilaterally after bevacizumab.

Implications:

  • Bilateral same-day intravitreal anti-VEGF injections are generally safe.
  • Clinicians should be aware of the potential for unilateral inflammation with bevacizumab.
  • Further monitoring may be warranted for specific agents or patient populations.
Abstract

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