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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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Published on: August 2, 2017

Pregnancy and laboratory studies: a reference table for clinicians.

Mina Abbassi-Ghanavati¹, Laura G Greer, F Gary Cunningham

¹From the University of Texas Southwestern Medical Center, Dallas, Texas.

Obstetrics and Gynecology

|November 26, 2009

Summary

Establishing pregnancy-specific laboratory reference ranges is crucial. Normal values for many common lab tests differ significantly in pregnant individuals compared to non-pregnant states, impacting accurate interpretation.

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Area of Science:

Clinical Chemistry
Obstetrics
Laboratory Medicine

Background:

Interpreting laboratory results during pregnancy requires careful consideration of physiological changes.
Existing laboratory reference ranges may not accurately reflect the pregnant state.

Purpose of the Study:

To establish normal reference ranges for common laboratory analytes during pregnancy.
To highlight the differences between pregnant and non-pregnant laboratory values.

Main Methods:

Comprehensive electronic database review (PubMed, MEDLINE) and textbook analysis.
Inclusion criteria focused on studies of uncomplicated pregnancies with specified gestational ages.
Data extraction and synthesis to determine 2.5th and 97.5th percentiles or min-max ranges.

Main Results:

Normal reference ranges for several laboratory markers were established for pregnancy.
Significant differences were observed in some laboratory markers between pregnant and non-pregnant individuals.
Data synthesis combined percentile ranges with min-max ranges from various sources.

Conclusions:

Pregnancy-specific reference ranges are essential for accurate interpretation of laboratory results.
Altered laboratory values due to normal pregnancy changes necessitate tailored reference intervals.
Clinical decisions should be informed by these pregnancy-specific ranges.