Related Experiment Video
Updated: Jun 18, 2026
09:14
Surgical Approach to Full Soft Tissue Face Allograft Procurement for Vascularized Composite Allotransplantation
Published on: December 30, 2025
Nasal dorsal augmentation with freeze-dried allograft bone
Richard P Clark1, Granger Wong, Loche M Johnson
1Sacramento, Calif.; and San Antonio, Texas From the University of California, Davis.
Plastic and Reconstructive Surgery
|November 26, 2009
Summary
Freeze-dried cortical allograft bone shows excellent graft volume persistence and vascularization for nasal augmentation. This safe and effective bone graft material demonstrates long-term stability in patients.
Area of Science:
- Orthopedic Surgery
- Biomaterials Science
- Regenerative Medicine
Background:
- Freeze-dried bone allografts have a strong safety record in orthopedic surgery since 1992.
- This study evaluates freeze-dried human cortical bone for nasal dorsal augmentation.
Observation:
- Cephalometric radiography assessed graft volume persistence.
- Fluorine-18 sodium fluoride PET/CT scans evaluated graft vascularization and incorporation.
Findings:
- Average graft projection persistence was 87% at 6 months, with 100% maintenance in 10 patients from 12 to 36 months.
- Vascularization and new bone formation within grafts were confirmed via PET/CT scans.
Implications:
- Initial volume loss is attributed to surgical edema; subsequent stability suggests successful integration.
- Two integration pathways are proposed: revascularization/inductive and scar bed barrier/noninductive.
- This study provides foundational data for long-term follow-up of freeze-dried allografts.
