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Inappropriate sinus tachycardia after hematopoietic stem cell transplantation
David Buchbinder1, Daniel S Levi, Alan Ikeda
1Department of Pediatric Hematology and Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. dbuchbinder@choc.org
Summary:
Survivors of childhood cancer and hematopoietic stem cell transplantation are subject to a range of cardiac late effects including conduction abnormalities. We present, the case of a 12-year-old girl diagnosed with inappropriate sinus tachycardia after a history of multiply relapsed acute lymphoblastic leukemia and an exposure history including anthracycline-based chemotherapy followed by the total body irradiation in the context of a hematopoietic stem cell transplant. The clinical importance of this late cardiac effect along with the potential options for therapy is discussed.
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