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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Should higher vancomycin trough levels be targeted for invasive community-acquired methicillin-resistant

Natalia Jimenez-Truque1, Isaac Thomsen, Elizabeth Saye

  • 1Department of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.

The Pediatric Infectious Disease Journal
|November 26, 2009
PubMed

Insights

Vancomycin resistance in pediatric MRSA (methicillin-resistant Staphylococcus aureus) remains stable. This study found no increase in vancomycin MICs in invasive pediatric MRSA isolates from 2004-2008.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pediatric Infectious Diseases

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen.
  • Elevated vancomycin minimum inhibitory concentrations (MICs) in MRSA are linked to poor outcomes in adults.
  • Understanding vancomycin susceptibility in pediatric MRSA is crucial for effective treatment.

Purpose of the Study:

  • To evaluate vancomycin MICs in invasive pediatric community-acquired MRSA isolates.
  • To determine if vancomycin MICs have increased over time in this population.

Main Methods:

  • Analysis of 71 invasive pediatric community-acquired MRSA isolates collected between 2004 and 2008.
  • Determination of vancomycin MICs using both E-test micromethod and E-test macro-method.

Main Results:

  • The modal vancomycin MIC observed was 1.5 microg/mL using the micromethod.
  • Median vancomycin MICs did not demonstrate an increasing trend over the study period (2004-2008).

Conclusions:

  • Vancomycin susceptibility in invasive pediatric MRSA isolates remained consistent during the study period.
  • The findings suggest a stable susceptibility profile, which is important for guiding pediatric MRSA treatment strategies.

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