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Related Experiment Video

Updated: Jun 18, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

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Pharmacologic side effects and/or neurologic disorder: case report.

Ljiljana Radanović-Grgurić¹, Anamarija Petek, Davor Laufer

¹University Department of Psychiatry, University Hospital Osijek, J Huttlera 4, 31000 Osijek, Croatia.

Psychiatria Danubina

|November 26, 2009

Summary

This case study explores a patient with schizophrenia who developed neurological symptoms, possibly Huntington

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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

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Published on: April 26, 2012

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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

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Published on: February 11, 2019

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Schizophrenia is a chronic psychiatric disorder.
Extrapyramidal symptoms (EPS) are common side effects of typical antipsychotics.
Atypical antipsychotics are often used to manage schizophrenia and reduce EPS.

Observation:

A patient with schizophrenia developed neurological symptoms, including extrapyramidal syndrome.
Treatment with typical neuroleptics led to EPS, prompting a switch to atypical antipsychotics.
The patient subsequently developed orofacial dyskinesias progressing to unilateral choreo-athetosis.

Findings:

Despite therapeutic adjustments, psychiatric and neurological symptoms remained largely unresponsive.
Brain MRI revealed moderate cortical atrophy.
Pharmacological resistance raised suspicion for an underlying neurological disorder, such as Huntington's chorea.

Implications:

This case highlights the complex interplay between psychiatric and neurological disorders.
It raises questions about whether the neurological disorder precipitated psychosis or if antipsychotic medication accelerated neurological decline.
Further research is needed to understand the diagnostic and therapeutic challenges in such co-occurring conditions.