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Related Experiment Videos

Morphometry of the human lamina cribrosa surface.

J B Jonas1, C Y Mardin, U Schlötzer-Schrehardt

  • 1Department of Ophthalmology, University Erlangen-Nürnberg, FRG.

Investigative Ophthalmology & Visual Science
|February 1, 1991
PubMed
Summary

The lamina cribrosa

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Area of Science:

  • Ophthalmology and Optometry
  • Neuroscience
  • Biomechanics

Background:

  • The lamina cribrosa, a sieve-like structure in the sclera, is crucial for optic nerve health and a primary site for glaucoma damage.
  • It facilitates the passage of retinal ganglion cell axons and central retinal vessels while maintaining ocular pressure gradients.

Purpose of the Study:

  • To morphometrically evaluate the inner surface of the lamina cribrosa in normal human donor eyes.
  • To investigate the relationship between pore characteristics, lamina cribrosa size, and potential glaucoma susceptibility.

Main Methods:

  • Electron microscopy was used to analyze the lamina cribrosa's inner surface in 40 human donor eyes.
  • Morphometric analysis focused on pore size, count, density, and their distribution across different regions.

Main Results:

  • Pore size and summed pore area were larger in the superior and inferior regions compared to nasal and temporal regions.
  • Pore characteristics were independent of age, sex, and lamina cribrosa shape, but pore count and summed pore area increased with lamina cribrosa size.
  • Vessel opening size was independent of lamina cribrosa size, potentially explaining unrelated central retinal vessel occlusions.

Conclusions:

  • Regional differences in pore size and ratio may contribute to glaucoma susceptibility in the superior and inferior optic disc.
  • The lack of correlation between lamina cribrosa size and vessel opening area may explain why central retinal vessel occlusions occur irrespective of optic disc size.

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