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Related Experiment Video

Updated: Jun 18, 2026

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Fluorescence tomographic imaging using a handheld-probe-based optical imager: extensive phantom studies.

Jiajia Ge¹, Sarah J Erickson, Anuradha Godavarty

¹Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, 10555 West Flagler Street EC 2675, Miami, Florida 33174, USA.

|November 26, 2009

Summary

This summary is machine-generated.

A new handheld optical imager shows promise for breast cancer detection using 3D fluorescence tomography. This portable device achieved 43% sensitivity and 95% specificity in phantom studies.

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Published on: July 17, 2012

Area of Science:

Biomedical Optics
Medical Imaging
Optical Engineering

Background:

Handheld-probe-based optical imagers offer portability and patient comfort for breast imaging.
Developing advanced imaging techniques is crucial for early disease detection.

Purpose of the Study:

To develop and demonstrate the feasibility of a novel handheld-probe-based optical imager for 3D fluorescence tomographic imaging.
To assess the performance limits of this imager using phantom studies.

Main Methods:

Developed a novel handheld-probe-based optical imager.
Conducted extensive 3D fluorescence tomography studies on large slab phantoms (650 ml).
Varied target volumes (0.1-0.45 cm3), target depths (1-3 cm), and fluorescence absorption contrast ratios.

Main Results:

Demonstrated the feasibility of 3D fluorescence tomographic imaging with the handheld device.
Evaluated performance across a range of target sizes, depths, and contrast ratios.
Achieved an estimated sensitivity of 43% and specificity of 95% in phantom experiments.

Conclusions:

The developed handheld optical imager is feasible for 3D fluorescence tomographic imaging.
The study provides performance benchmarks for this technology in breast imaging applications.
Further research is warranted to optimize sensitivity for clinical translation.