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Related Concept Videos

Community Based Intervention01:30

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Related Experiment Video

Updated: Jun 18, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Ten lessons learned from conducting an adherence intervention trial.

Jeannie K Lee1, Karen A Grace, Allen J Taylor

  • 1College of Pharmacy, University of Arizona, Tucson, AZ, USA;

Patient Preference and Adherence
|November 26, 2009
PubMed
Summary

The Federal study of Adherence to Medications in the Elderly (FAME) trial offers key lessons for improving medication adherence and health outcomes in older adults with polypharmacy. Implementing these strategies can enhance clinical practice research effectiveness.

Keywords:
adherenceinterventionmedicationpharmacist

Related Experiment Videos

Last Updated: Jun 18, 2026

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation
09:42

Using Continuous Data Tracking Technology to Study Exercise Adherence in Pulmonary Rehabilitation

Published on: November 8, 2013

Area of Science:

  • Gerontology
  • Clinical Pharmacy
  • Health Services Research

Background:

  • Clinical practice research offers unique insights into diverse patient populations across various healthcare settings.
  • The Federal study of Adherence to Medications in the Elderly (FAME) was a pioneering prospective observational and randomized controlled trial.
  • This trial focused on enhancing medication adherence and health outcomes in elderly patients with polypharmacy.

Purpose of the Study:

  • To describe ten essential lessons learned from conducting the FAME adherence intervention trial.
  • To provide guidance for future clinical practice research involving medication adherence in older adults.
  • To highlight strategies for successful implementation and management of adherence trials.

Main Methods:

  • The FAME trial employed a prospective observational and randomized controlled design.
  • Intervention strategies were developed and tested to improve medication adherence.
  • Data were collected on adherence rates and associated health outcomes in elderly patients.

Main Results:

  • Ten key lessons were identified from the trial's execution.
  • These lessons cover trial linkage to clinical work, understanding adherence, individualized interventions, tailored criteria, outcome selection, team support, teamwork, limitation consideration, grant acquisition, and findings dissemination.
  • The study emphasizes practical strategies for conducting effective adherence research.

Conclusions:

  • Successful adherence intervention trials require careful planning and execution.
  • Integrating research with clinical practice and engaging multidisciplinary teams are crucial.
  • Disseminating findings is vital for advancing the care of older adults with polypharmacy.