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Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
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Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
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Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...

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An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
09:14

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Published on: January 26, 2019

Compliance with RSV prophylaxis: Global physicians' perspectives.

Kari S Anderson1, Victoria M Mullally, Linda M Fredrick

  • 1Abbott Laboratories, Abbott Park, IL, USA.

Patient Preference and Adherence
|November 26, 2009
PubMed
Summary

Pediatricians identified caregiver inconvenience, cost, and lack of understanding as key barriers to palivizumab (RSV antibody) prophylaxis compliance in infants. Educational materials and home administration could improve adherence to this vital respiratory syncytial virus (RSV) prevention.

Keywords:
immunizationinfantmedication adherencepassiveprematurerespiratory syncytial virus infections

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Respiratory syncytial virus (RSV) is a major cause of illness in high-risk infants.
  • Palivizumab prophylaxis is effective in preventing serious RSV disease, but requires strict monthly dosing during the RSV season.
  • Ensuring compliance with palivizumab prophylaxis is critical for infant protection.

Purpose of the Study:

  • To identify pediatrician perspectives on barriers to palivizumab prophylaxis compliance.
  • To explore physician-recommended interventions to improve palivizumab prophylaxis adherence.
  • To understand global challenges in maintaining prophylaxis schedules for high-risk infants.

Main Methods:

  • A survey was distributed to 453 pediatricians worldwide.
  • 100 physicians from five continents completed the survey.
  • The survey focused on barriers to compliance and potential interventions for palivizumab prophylaxis.

Main Results:

  • Common barriers identified include caregiver inconvenience, clinic distance, cost, and poor understanding of RSV severity.
  • Recommended interventions include providing educational materials, hospital/clinic reminders, and home-based prophylaxis administration.
  • Physicians globally acknowledge significant obstacles to prophylaxis compliance.

Conclusions:

  • Caregiver inconvenience and lack of understanding are primary reasons for noncompliance with palivizumab prophylaxis.
  • Proactive interventions, such as caregiver education and reducing logistical burdens, are crucial for improving RSV prophylaxis adherence.
  • Addressing identified barriers can enhance the effectiveness of palivizumab in preventing severe RSV illness in infants.