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G protein subunit dissociation and translocation regulate cellular response to receptor stimulation

Mariangela Chisari1, Deepak Kumar Saini, Joon-Ho Cho

  • 1Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Plos One
|November 26, 2009
PubMed
Summary

Cellular signaling intensity is modulated by G protein behavior. Receptor activation causes G betagamma translocation, which can attenuate cellular responses, while non-dissociating G betagamma enhances them.

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