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07:49
A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
Chronic heart failure and exercise intolerance: the hemodynamic paradox
Kent R Nilsson1, Brian D Duscha, Patrick M Hranitzky
1Department of Medicine, Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Current Cardiology Reviews
|November 26, 2009
Summary
Heart failure significantly impacts quality of life, especially in older adults. Skeletal muscle changes, not just hemodynamics, explain symptoms, with gender influencing disease and treatment.
Area of Science:
- Cardiology
- Exercise Physiology
- Geriatrics
Background:
- Heart failure is a leading cause of morbidity, mortality, and hospitalizations in adults over 65.
- Chronic heart failure symptoms like fatigue and dyspnea severely impact patient quality of life.
- Economic costs associated with heart failure are substantial.
Purpose of the Study:
- To review the systemic effects of heart failure.
- To explore the "hemodynamic paradox" and its link to skeletal muscle alterations.
- To examine the impact of exercise training and cardiac resynchronization therapy on heart failure.
Main Methods:
- Review of current literature on heart failure pathophysiology.
- Analysis of enzymatic, histologic, and neurohumoral alterations in heart failure.
- Discussion of gender-specific effects on heart failure.
Main Results:
- Hemodynamic derangements do not always correlate with heart failure symptoms.
- Skeletal muscle alterations play a key role in the "hemodynamic paradox" of heart failure.
- Gender-specific factors influence heart failure progression and treatment response.
Conclusions:
- Understanding systemic effects, particularly skeletal muscle changes, is crucial for managing heart failure.
- Exercise training and cardiac resynchronization therapy show potential in altering the disease course.
- Further research into gender-specific aspects of heart failure is warranted.
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