Effect of external pH on heat sensitization by local anesthetics

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Updated: Oct 13, 2026

Determining heat and mechanical pain threshold in inflamed skin of human subjects
13:21

Determining heat and mechanical pain threshold in inflamed skin of human subjects

Published on: January 13, 2009

R A Coss1, N N Smith

  • 1Department of Radiation Oncology and Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107-5004.

International Journal of Radiation Oncology, Biology, Physics
|January 1, 1991
PubMed

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The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
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