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The chemistry and biology of LL-37

Matthew F Burton1, Patrick G Steel

  • 1Centre for Bioactive Chemistry, Department of Chemistry, University of Durham, Science Laboratory, South Road, Durham, DH1 3LE, UK. m.f.burton@durham.ac.uk

Natural Product Reports
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Laminins are heterotrimeric proteins with high molecular mass found in the extracellular matrix. Each laminin molecule is composed of three chains, viz. alpha, beta, and gamma, coded by five, four, and three paralogous genes, respectively. Laminins are categories based on the compositions of the three chains.
In humans, the five forms of alpha chains are LAMA 1, LAMA 2, LAMA 3, LAMA 4, and LAMA 5. The four forms of beta chains are LAMB 1, LAMB 2, LAMB 3, and LAMB 4. The three forms of gamma...