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Understanding the evolutionary relationships among microorganisms is fundamental to microbial ecology and taxonomy. Phylogenetic trees are essential tools for inferring these relationships, relying primarily on comparative analyses of molecular sequences such as DNA, RNA, or proteins. In microbial studies, these trees typically depict the evolutionary paths of diverse bacterial and archaeal species by mapping genetic differences accumulated over time.Phylogenetic trees are composed of tips,...
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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
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Published on: March 12, 2020

Phylogenetic methods in natural product research.

Imke Schmitt1, F Keith Barker

  • 1Department of Plant Biology and Bell Museum of Natural History, University of Minnesota, 250 Biological Sciences Center, 1445 Gortner Ave., St. Paul, MN 55108, USA. schm2109@umn.edu

Natural Product Reports
|November 26, 2009
PubMed
Summary

Natural products research increasingly uses evolutionary analyses based on phylogenetic trees. This review covers methods and software for inferring and applying these evolutionary trees in the field.

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Area of Science:

  • Evolutionary biology
  • Bioinformatics
  • Natural products chemistry

Background:

  • Phylogenetic tree inference and analysis are rapidly advancing fields.
  • Keeping up with new phylogenetic methodologies is challenging for researchers.
  • Natural products research increasingly utilizes evolutionary analyses.

Purpose of the Study:

  • To summarize phylogenetic applications in natural products research.
  • To review methods and software for phylogenetic tree inference and analysis.
  • To provide an updated overview of alignment and phylogenetic analysis tools.

Main Methods:

  • Literature review focusing on phylogenetic methods and applications in natural products research.
  • Coverage of alignment methods and software (2000-2009).
  • Review of phylogenetic analysis tools (1990-2009).

Main Results:

  • Identified key phylogenetic applications in natural products research.
  • Provided an overview of available alignment and phylogenetic inference software.
  • Highlighted useful tools for evolutionary analyses.

Conclusions:

  • Phylogenetic methods are essential tools for modern natural products research.
  • Researchers can benefit from this review to navigate available phylogenetic tools and methods.
  • The review serves as a guide to integrating evolutionary perspectives into natural products studies.