C-reactive protein in acute coronary syndrome: association with 3-year outcomes

Area of Science:

• Cardiology
• Biomarkers
• Inflammation

Background:

• Inflammatory markers are linked to outcomes in acute coronary syndrome (ACS).
• High-sensitivity C-reactive protein (CRP) is a key inflammatory marker.
• Predictive value of CRP for long-term outcomes in ACS needs further evaluation.

Purpose of the Study:

• To assess high-sensitivity C-reactive protein (CRP) as a predictor of late cardiovascular outcomes in ACS patients.
• To evaluate the association between baseline CRP levels and major adverse cardiovascular events (MACE) and mortality.
• To determine the prognostic significance of CRP for long-term prognosis after ACS.

Main Methods:

• Prospective study of 199 ACS patients.
• Clinical reassessment approximately 3 years post-discharge.
• Statistical analysis included Cox multivariable analysis and Kaplan-Meier survival curves.
• Evaluation of clinical variables and CRP levels as predictors of MACE and mortality.

Main Results:

• Patients with MACE had significantly higher baseline CRP levels (median 0.67 mg/L vs 0.45 mg/L, P < 0.001).
• CRP levels >3 mg/L were associated with significantly lower survival rates (P = 0.001).
• High CRP (>3 mg/L) predicted MACE (OR 7.41) and all-cause mortality (HR 4.58) compared to low CRP (<1 mg/L).

Conclusions:

• High-sensitivity C-reactive protein (CRP) is a significant predictor of worse long-term outcomes in ACS patients.
• Elevated CRP levels identify patients at increased risk for major adverse cardiovascular events and mortality.
• CRP measurement can aid in risk stratification and management of ACS patients for improved long-term prognosis.