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Low grade cerebellar T-cell lymphoma: a novel response to treatment; a case report
Robert Corns1, Matthew Crocker, Atul Kumar
1Departments of Neurosurgery, King's College Hospital, Denmark Hill, London SE5 9RS, UK. cilfodan@hotmail.com
Abstract:
Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T-cell phenotype and a Ki67 proliferation index of only 1%. Contrary to the prevailing view in the literature, the patient's clinical condition deteriorated following high-dose intravenous methotrexate and improved after a short course of whole-brain radiotherapy.
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