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Disseminated protothecosis.

Leni G Mathew1, Susanne Pulimood, Meera Thomas

  • 1Department of Child Health, Christian Medical College, Vellore, South India, India. lenimathew@cmcvellore.ac.in

Indian Journal of Pediatrics
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

This report details a rare case of disseminated protothecosis in an Indian child with combined immunodeficiency. The infection proved resistant to amphotericin B, highlighting challenges in treating this rare disease.

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Area of Science:

  • Medical Mycology
  • Immunology
  • Infectious Diseases

Background:

  • Disseminated protothecosis is a rare infection caused by Prototheca species.
  • Combined immunodeficiency (CID) increases susceptibility to opportunistic infections.
  • Prototheca species are achlorophyllous algae that can cause human infections.

Observation:

  • A 10-year-old boy with CID presented with disseminated protothecosis.
  • Clinical diagnosis was challenging, with symptoms including skin lesions and splenomegaly.
  • Laboratory identification relied on observing sporangiospores in culture.

Findings:

  • The patient experienced treatment failure with amphotericin B.
  • Recurrence of olecranon bursitis was noted post-treatment.
  • Disseminated protothecosis in this context is previously unreported from India.

Implications:

  • This case highlights the diagnostic difficulties of protothecosis.
  • It underscores the limited treatment options and potential for recurrence in immunocompromised patients.
  • Further research into effective therapies for disseminated protothecosis is warranted.