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Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1

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Maternal high-fat diet: effects on offspring bone structure.

S A Lanham¹, C Roberts, T Hollingworth

¹Bone and Joint Research Group, Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, UK. S.A.Lanham@soton.ac.uk

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

|November 26, 2009

Summary

This summary is machine-generated.

Maternal high-fat diet during pregnancy alters offspring bone structure and increases marrow adiposity. This suggests in utero nutrition programs skeletal development and has consequences later in life.

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Area of Science:

Reproductive biology
Skeletal biology
Nutritional science

Background:

Peak bone mass is influenced by early life nutrition.
Intrauterine and early postnatal environments may program skeletal development.
Maternal diet during gestation is a critical factor in fetal programming.

Purpose of the Study:

To investigate the hypothesis that peak bone mass has a fetal origin.
To examine the effects of maternal high-fat diet on offspring bone development in a mouse model.
To determine if in utero nutrition programming impacts skeletal structure and adiposity.

Main Methods:

Mouse dams were fed either a standard chow or a high-fat diet throughout gestation and lactation.
Offspring were maintained on a high-fat diet until adulthood (30 weeks).
Femur samples were analyzed for bone structure, adiposity, and strength.

Main Results:

Offspring from dams fed a high-fat diet exhibited increased femur adiposity compared to controls.
Female offspring from high-fat diet dams showed altered trabecular bone structure.
These structural changes indicate programming due to in utero nutrition.

Conclusions:

Maternal high-fat diet during pregnancy leads to increased bone marrow adiposity in offspring.
In utero exposure to a high-fat diet alters offspring bone structure.
Maternal nutrition during pregnancy has lasting effects on offspring skeletal development.