Novel/conceptual floating pulsatile system using high internal phase emulsion based porous material intended for...

Area of Science:

• Materials Science
• Pharmaceutical Sciences
• Drug Delivery

Background:

• Chronotherapy requires precise drug release timing, often challenging with conventional formulations.
• Existing drug delivery systems for arthritis face limitations like complex formulations and multiple excipients.
• Optimizing drug loading and release profiles is crucial for effective chronotherapeutic strategies.

Purpose of the Study:

• To design a novel porous delivery system for ibuprofen for arthritis chronotherapy.
• To overcome formulation limitations by using a porous material and optimizing drug loading.
• To achieve a desired drug release profile suitable for in vitro investigations and targeted absorption.

Main Methods:

• Synthesized a porous carrier using high internal phase emulsion with styrene and divinylbenzene.
• Employed a 3(2) factorial design for optimizing drug loading via solvent evaporation.
• Evaluated drug loading, encapsulation efficiency, and surface characteristics using SEM, AFM, and in vitro release studies.
• Investigated the impact of solvent volume, drug amount, and polarity (methanol vs. dichloromethane) on drug adsorption and release.

Main Results:

• Drug loading optimization favored the low-polarity solvent dichloromethane.
• Overall drug release varied significantly: 0.98-52% in acidic medium and 71-94% in basic medium.
• Achieved a minimal drug release of 0.98% without employing any release modifiers.

Conclusions:

• The developed porous delivery system offers a unique approach for ibuprofen chronotherapy in arthritis.
• The system successfully overcomes formulation complexities and achieves controlled release without additional modifiers.
• This novel system demonstrates potential for time- and controlled-release applications, distinct from existing technologies.