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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

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Apolipoprotein D synthesis progressively increases in frontal cortex during human lifespan.

Ana Navarro¹, Eva del Valle, Amalia Juárez

¹Departamento de Morfología y Biología Celular, Universidad de Oviedo, Oviedo 33006, Spain.

Age (Dordrecht, Netherlands)

|November 26, 2009

Summary

Apolipoprotein D (apo D) expression increases with age in the human brain, particularly in white matter. This suggests apo D plays a crucial role in protecting against aging-related cellular damage.

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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

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Published on: November 26, 2017

Area of Science:

Neuroscience
Aging Research
Cellular Biology

Background:

Apolipoprotein D (apo D) is a lipocalin found in the nervous system, implicated in reinnervation, regeneration, and neuronal protection.
Altered apo D expression is linked to normal brain aging and neurodegenerative diseases in specific brain regions.

Purpose of the Study:

To investigate the regional and cellular expression patterns of apo D in the normal human brain throughout the aging process.
To understand the role of apo D in central nervous system aging and its potential protective mechanisms.

Main Methods:

Utilized slot-blot techniques for quantifying protein and mRNA levels of apo D.
Employed immunohistochemistry and hybridohistochemistry for cellular localization of apo D synthesis.
Examined post-mortem human cerebral cortex samples.

Main Results:

A positive correlation was observed between apo D expression and chronological aging.
Both apo D mRNA and protein levels were significantly higher in white matter compared to grey matter.
Immunohistochemistry and in situ hybridization revealed apo D synthesis in both neurons and glial cells, notably oligodendrocytes. The number of apo D-synthesizing neurons increased with age.

Conclusions:

Apolipoprotein D plays a fundamental role in the aging of the central nervous system.
Increased apo D expression with age may represent a cellular defense mechanism against lipid peroxidation products and other age-related deleterious effects.