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Related Experiment Video

Updated: Jun 18, 2026

An Efficient Single-Person Technique for Milk Sampling from Laboratory Mice
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An Efficient Single-Person Technique for Milk Sampling from Laboratory Mice

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Methods for collecting milk from mice.

Edward J DePeters1, Russell C Hovey

  • 1Department of Animal Science, University of California, Davis, 2145 Meyer Hall, One Shields Avenue, Davis, CA 95616, USA.

Journal of Mammary Gland Biology and Neoplasia
|November 26, 2009
PubMed
Summary

Researchers developed two simple, non-invasive methods for collecting milk from lactating mice. These techniques provide sufficient milk volumes for detailed mammary gland and lactation studies, proving valuable for genetic research.

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Area of Science:

  • * Reproductive Biology
  • * Mammalian Lactation
  • * Animal Models in Research

Background:

  • * Studying mammary gland biology and lactation in mice is crucial for understanding reproductive health.
  • * Phenotypes, particularly those resulting from genetic modifications, often manifest during lactation.
  • * Adequate milk collection is essential for analyzing these lactation-dependent phenotypes.

Purpose of the Study:

  • * To present two accessible and non-invasive methods for milk collection from lactating mice.
  • * To provide researchers with practical techniques for obtaining sufficient milk volumes for analysis.
  • * To facilitate the study of mammary gland function and genetic modifications in mouse models.

Main Methods:

  • * Description of two distinct, non-invasive milk collection techniques from lactating mice.

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  • * Emphasis on the simplicity and low cost of both methods.
  • * Validation of the methods for yielding adequate milk volumes for subsequent analyses.

    • Main Results:

    • * Both described methods are inexpensive and easy to implement in laboratory or classroom settings.
    • * The techniques are non-invasive, minimizing stress to the animals.
    • * Sufficient milk volumes were obtained for various downstream analytical procedures.

    Conclusions:

    • * The presented methods offer practical solutions for milk collection in mouse models.
    • * These techniques support the investigation of mammary gland biology and lactation-dependent phenotypes.
    • * The approaches are suitable for both research and educational purposes, enhancing the utility of mouse models.