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A single-center experience with intracardiac thrombosis in children with dilated cardiomyopathy

Soo-Han Choi1, Soo In Jeong, Ji-Hyuk Yang

  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

Pediatric Cardiology
|November 26, 2009
PubMed

Insights

Intracardiac thrombosis occurs in 6% of children with dilated cardiomyopathy, often during rapid ventricular dysfunction. Early anticoagulation is crucial for preventing serious complications in these high-risk pediatric patients.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Research
  • Hematology

Background:

  • Dilated cardiomyopathy in children poses significant risks.
  • Intracardiac thrombosis is a life-threatening complication associated with this condition.

Purpose of the Study:

  • To determine the incidence, risk factors, and outcomes of intracardiac thrombosis in pediatric patients with dilated cardiomyopathy.
  • To highlight the importance of early detection and management.

Main Methods:

  • Retrospective review of clinical records of 83 children diagnosed with dilated cardiomyopathy between 1995 and 2008.
  • Analysis of patient data to identify thrombus formation, location, and associated clinical factors.

Main Results:

  • Intracardiac thrombi were identified in 5 patients (6.0%).
  • Thrombi were predominantly located in the left ventricle, associated with poor ejection fraction and rapid ventricular function deterioration.
  • All patients received heparinization; one underwent thrombectomy, with three achieving complete resolution.

Conclusions:

  • Intracardiac thrombosis is a notable complication in children with dilated cardiomyopathy, particularly those with impaired ventricular function.
  • Aggressive anticoagulation and vigilant monitoring are essential for preventing embolic events and managing intracardiac thrombosis in this vulnerable population.

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