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Updated: Jun 18, 2026
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Cardiac resynchronization therapy is effective even in elderly patients with comorbidities
Natália António1, Carolina Lourenço, Rogério Teixeira
1Department of Cardiology, Coimbra University Hospital and Medical School, Avenida Bissaya Barreto, 3000-076, Coimbra, Portugal. natalia.antonio@gmail.com
Summary
Elderly patients show similar benefits from cardiac resynchronization therapy (CRT) as younger patients, with comorbidities not hindering CRT success. This therapy is effective regardless of age.
Area of Science:
- Cardiology
- Medical Devices
- Geriatrics
Background:
- Cardiac resynchronization therapy (CRT) is a treatment for heart failure.
- Its effectiveness in elderly patients with comorbidities requires further investigation.
Purpose of the Study:
- To compare CRT effects in elderly (>=65 years) versus younger patients.
- To assess comorbidity impact on CRT remodeling response.
Main Methods:
- Prospective study of 87 patients undergoing CRT.
- Clinical and echocardiographic evaluations pre- and post-CRT (6 months).
- Remodeling response defined by LVESV reduction; clinical response by NYHA class improvement.
Main Results:
- Elderly and younger patients showed similar improvements in LV ejection fraction, LVESV, LV dP/dt, and mitral regurgitation.
- Comparable rates of clinical and remodeling responders, with no significant difference in hospitalizations.
- Predictors of poor remodeling included QRS duration <120 ms, LV diastolic diameter >74 mm, and JA >10 cm²; comorbidities were not significant predictors.
Conclusions:
- Age is not a barrier to successful CRT outcomes.
- CRT is effective in elderly patients, even with comorbidities.
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