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Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
Published on: September 23, 2022
[Pitfalls in the diagnosis of tick-borne encephalitis in vaccinated patients]
Hana Zelená1, Jirí Januska, Jan Raszka
1Department of Virology, National Reference Laboratory for Arboviruses, Institute of Public Health, Ostrava, Czech Republic. Hana.Zelena@zuova.cz
Abstract:
The authors draw attention to diagnostic pitfalls in tick born encephalitis serology in vaccinated people. Benefits and limitations of particular serologic methods are demonstrated by case study of a patient with a failure of anti-TBEV vaccination. It is necessary to examine paired serum samples in previously vaccinated patients with suspicion of tick born encephalitis and to demonstrate significant increase of antibodies titers for confirmation of the diagnosis. The virusneutralisation assay is considered a method of choice in these special cases.
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