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Updated: Jun 18, 2026
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Single Port Donor Nephrectomy
Published on: March 12, 2011
Randomized clinical trial of laparoscopic versus open donor nephrectomy
M L Nicholson1, M Kaushik, G R R Lewis
1Transplant Surgery Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. mln2@le.ac.uk
The British Journal of Surgery
|November 26, 2009
Summary
Laparoscopic donor nephrectomy (LDN) offers improved recovery for live kidney donors, including less pain and shorter hospital stays, without affecting transplant outcomes. This makes live kidney donation more appealing and safer for donors.
Area of Science:
- Nephrology
- Surgical Innovation
- Transplantation
Background:
- Live kidney donation is crucial for transplantation.
- Minimally invasive techniques aim to reduce donor morbidity.
- Laparoscopic donor nephrectomy (LDN) is an alternative to open donor nephrectomy (ODN).
Purpose of the Study:
- To compare the safety and efficacy of LDN versus short-incision ODN.
- To evaluate donor recovery parameters and surgical outcomes.
Main Methods:
- A randomized controlled trial involving 84 live kidney donors.
- Donors were randomized 2:1 to LDN (56) or short-incision ODN (28).
- Primary endpoints included pain relief and inpatient stay duration.
Main Results:
- LDN resulted in significantly less pain (morphine use) and shorter hospital stays.
- Donors undergoing LDN returned to employment sooner and had improved postoperative respiratory function.
- While operative time and warm ischemia were longer in LDN, there were fewer postoperative complications per donor compared to ODN.
- No donor deaths or allograft thromboses occurred in either group.
- Long-term follow-up showed no difference in renal function or allograft survival.
Conclusions:
- LDN is a safe and effective alternative to ODN.
- LDN reduces barriers to live kidney donation by improving donor recovery.
- The procedure does not compromise recipient transplant outcomes.
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