Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel biomarker of fibrosis in SSc-ILD.

RMD open·2026
Same author

Contrast-sparing CT using renal-clearable gold nanoclusters for early spatial mapping of renal dysfunction.

Science advances·2026
Same author

Chris Orvig: Celebrating His Career and Contributions to Inorganic Biochemistry.

Journal of inorganic biochemistry·2026
Same author

Collagen-binding probe PET/MR for distinguishing fibrotic from inflammatory strictures in Crohn's disease.

European journal of nuclear medicine and molecular imaging·2026
Same author

First-in-Human Study of the Carbohydrate Nanoparticle <sup>64</sup>Cu-Macrin.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2025
Same author

Author Correction: Manganese-based type I collagen-targeting MRI probe for in vivo imaging of liver fibrosis.

Npj imaging·2025

Related Experiment Video

Updated: Jun 18, 2026

An Aptamer-based Sensor for Unchelated Gadolinium(III)
05:15

An Aptamer-based Sensor for Unchelated Gadolinium(III)

Published on: January 9, 2017

Primer on gadolinium chemistry.

A Dean Sherry1, Peter Caravan, Robert E Lenkinski

  • 1Department of Chemistry, University of Texas at Dallas, Richardson, Texas, USA. dean.sherry@utsouthwestern.edu

Journal of Magnetic Resonance Imaging : JMRI
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

Gadolinium contrast agents

More Related Videos

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Related Experiment Videos

Last Updated: Jun 18, 2026

An Aptamer-based Sensor for Unchelated Gadolinium(III)
05:15

An Aptamer-based Sensor for Unchelated Gadolinium(III)

Published on: January 9, 2017

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
13:21

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging

Published on: July 21, 2011

Area of Science:

  • Inorganic chemistry
  • Radiochemistry
  • Biochemistry

Background:

  • Gadolinium (Gd) is a trivalent lanthanide ion crucial for magnetic resonance imaging (MRI) contrast agents.
  • Understanding Gd solution chemistry is vital due to its link with nephrogenic systemic fibrosis (NSF).
  • Basic principles of chelation, water hydration, and stability (thermodynamic vs. kinetic) are essential for comprehending Gd toxicity.

Purpose of the Study:

  • To provide a foundational understanding of gadolinium solution chemistry.
  • To elucidate the relationship between gadolinium complex stability and in vivo toxicity.
  • To highlight the critical role of kinetic inertness in mitigating gadolinium toxicity.

Main Methods:

  • Review of fundamental gadolinium solution chemistry principles.
  • Analysis of thermodynamic stability and kinetic inertness of gadolinium complexes.
  • Presentation of new data on a europium DOTA-tetraamide complex to illustrate kinetic stability's importance.

Main Results:

  • Kinetic dissociation rates are the primary determinant of in vivo gadolinium toxicity.
  • A novel europium DOTA-tetraamide complex, though thermodynamically unstable, demonstrated extraordinary kinetic inertness and low toxicity.
  • Literature evidence supports the axiom that kinetic stability, not thermodynamic stability, dictates gadolinium toxicity.

Conclusions:

  • The kinetic stability of a gadolinium complex is paramount in determining its in vivo toxicity.
  • Focusing on kinetic inertness is crucial for developing safer gadolinium-based contrast agents.
  • A deeper understanding of Gd chelation chemistry is necessary for clinical safety and efficacy.