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Oral L-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled

Tao Sun1, Wen-Bai Zhou, Xin-Ping Luo

  • 1Department of Cardiology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, P.R. China.

Clinical Cardiology
|November 26, 2009
PubMed

Insights

Oral L-arginine supplementation does not improve clinical outcomes for patients experiencing acute myocardial infarction (AMI). This meta-analysis found no significant difference in event rates or mortality between L-arginine and placebo groups.

Area of Science:

  • Cardiovascular Research
  • Clinical Nutrition
  • Medical Interventions

Background:

  • Oral L-arginine improves endothelial function in stable coronary artery disease (CAD).
  • The efficacy of L-arginine in acute myocardial infarction (AMI), a form of unstable CAD, remains uncertain.

Purpose of the Study:

  • To evaluate the impact of oral L-arginine supplementation on clinical outcomes in patients with AMI.
  • To synthesize evidence from completed randomized controlled trials.

Main Methods:

  • Systematic literature search of PubMed, Cochrane Library, Embase, and reference lists.
  • Meta-analysis of randomized, placebo-controlled trials involving L-arginine supplementation in AMI patients.
  • Independent assessment of trials by two reviewers, with consensus for discrepancies.

Main Results:

  • Two trials with 927 participants were included in the meta-analysis.
  • No significant difference in event rates was observed between L-arginine and placebo groups.
  • A non-significant 7% reduction in mortality was noted in the L-arginine group (RR: 0.93, 95% CI: 0.74-1.17).

Conclusions:

  • Oral L-arginine supplementation demonstrates no significant effect on clinical outcomes for patients with acute myocardial infarction.
  • Current evidence does not support the use of L-arginine for improving outcomes in AMI patients.
Abstract

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