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Related Experiment Video

Updated: Jun 18, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
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[Micro-CT system based on the flat panel detector for small animal imaging].

Xiao-Quan Yang1, Yong Deng, Zi-Lin Deng

  • 1Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology.

Zhongguo Yi Liao Qi Xie Za Zhi = Chinese Journal of Medical Instrumentation
|November 27, 2009
PubMed
Summary

This paper introduces a high-resolution Micro-CT system for small animal imaging, achieving 185 m resolution. The system clearly images rabbit thighbone trabecular bone, demonstrating its small animal imaging capabilities.

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Area of Science:

  • Medical imaging
  • Biomedical engineering
  • X-ray technology

Context:

  • Small animal imaging is crucial for preclinical research.
  • High-resolution imaging systems are needed for detailed anatomical studies.
  • Existing systems may lack the necessary resolution for specific micro-anatomical features.

Purpose:

  • To introduce a novel high-resolution Micro-CT system.
  • To detail the system's technical specifications and performance.
  • To demonstrate its capability for imaging small animal bone structures.

Summary:

  • A Micro-CT system utilizing a 100 micrometer focal spot X-ray tube and a 13cm x 13cm flat panel detector is presented.
  • Cone beam reconstruction algorithms are employed for data processing.

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  • The system achieves a resolving power of 31 lp/cm (at 10% MTF) and a spatial resolution of 185 m at 1.94x magnification.

    • Impact:

    • Enables clearer visualization of micro-anatomical structures in small animals.
    • Facilitates advanced preclinical research requiring detailed bone imaging.
    • Demonstrates a significant advancement in small animal Micro-CT imaging technology.