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[Study on sugarcane alkane alcohol to quail hyperlipidemia and atherosclerosis model]
Zhongfeng Shi1, Qixin Yan, Jinhua Zhao
1Guangdong Pharmaceutical University, Center Laboratory, Guangzhou 510006, China. shizhf@139.com
Objective:
To study on pharmacologic actions on quail hyperlipidemia and atherosclerosis model.
Method:
To duplicate quail hyperlipidemia model by ectogenesis cholesterol and high fat forage, induce to atherosclerosis model, observe influence of sugarcane alkane alcohol to model animals' blood fat level, formation of atherosclerosis plaque, pathological changes of coronary vessels and vascular intimal.
Result:
TC, TG, LDL-C level in blood serum of quail hyperlipidemia markedly decreased after administered sugarcane alkane alcohol by dose of 30, 15, 7.5 mg x kg(-1), proliferation of aorta and brachiocephalic artery tunica intima foam cells was suppressed.
Conclusion:
Sugarcane alkane alcohol has satisfactory pharmacologic actions on hyperlipidemia and atherosclerosis animal model by regulating blood fat.
