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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

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Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
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Chronic cough--about a clinical case...

Gorete Fonseca1

  • 1Centro de Saúde da Lousã, Lousã, Portugal. gmfonseca@iol.pt

Clinical Drug Investigation
|November 27, 2009
PubMed
Summary
This summary is machine-generated.

Gastro-oesophageal reflux disease (GORD) can cause chronic cough, often with difficult diagnosis due to extra-oesophageal symptoms. Prompt family doctor investigation led to successful diagnosis and treatment with pantoprazole.

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Area of Science:

  • Gastroenterology
  • Pulmonology
  • Internal Medicine

Background:

  • Gastro-oesophageal reflux is a common cause of chronic cough.
  • Diagnosing extra-oesophageal manifestations of GORD can be challenging.
  • Chronic cough requires thorough investigation beyond respiratory causes.

Observation:

  • A 20-year-old chronic smoker presented with a persistent cough since 2004.
  • Previous treatments for presumed respiratory infections were ineffective.
  • Cardiorespiratory investigations were normal, prompting investigation of the upper digestive tract.

Findings:

  • Endoscopy confirmed gastro-oesophageal reflux as the cause of the chronic cough.
  • The patient experienced symptomatic relief after treatment with pantoprazole 40 mg.
  • Early consultation with a family doctor facilitated timely diagnosis.

Implications:

  • Highlights the importance of considering GORD in cases of unexplained chronic cough.
  • Emphasizes the need to recognize and manage extra-oesophageal manifestations of GORD.
  • Suggests that a primary care approach can effectively diagnose and treat GORD-related chronic cough.