Related Experiment Video
Updated: Jun 18, 2026
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?
Simon Fishel1, Anthony Gordon, Colleen Lynch
1CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom. simon.fishel@carefertility.com
Objective:
To ascertain meiotic aneuploidy of the human egg using array comparative genomic hybridization to evaluate the 23-paired chromosome copy number of first polar body as an objective prognosticator of embryo viability for embryo transfer in the same cycle.
Design:
Case report.
Setting:
Independent-sector IVF program.
Patient(S):
A 41-year-old woman with a history of 13 failed cycles of IVF.
Intervention(S):
Polar body biopsy of metaphase II eggs.
Main Outcome Measure(S):
Birth.
Result(S):
Two of the nine eggs were euploid, and the resulting embryos, although morphologically inferior to sibling embryos, were selected for transfer to the uterus, resulting in the birth of a normal healthy baby.
Conclusion(S):
Selection of euploid eggs, as an objective parameter of subsequent embryo viability and with the opportunity to transfer embryos in the same cycle could maximise the opportunity for live birth after IVF even in cases with poor prognosis.
Related Concept Videos
01:24In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
01:57Meiosis II
01:38Fertilization