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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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A novel immobilization multienzyme glucose fluorescence capillary biosensor.

Yong-Sheng Li¹, Yun-Dong Du, Ting-Mei Chen

¹School of Chemical Engineering, Sichuan University, Chengdu, China. li-yongsheng@scu.edu.cn

Biosensors & Bioelectronics

|November 27, 2009

Summary

A novel glucose biosensor uses immobilized enzymes and fluorescence detection for sensitive glucose measurement. This method offers accurate serum glucose determination, aiding in diabetes diagnosis.

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Highly Sensitive and Rapid Fluorescence Detection with a Portable FRET Analyzer

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Area of Science:

Biotechnology
Analytical Chemistry
Biosensors

Background:

Accurate glucose monitoring is crucial for diabetes management.
Existing methods may have limitations in sensitivity or sample volume.

Purpose of the Study:

To develop a highly sensitive fluorescence biosensor for glucose determination.
To optimize the biosensor for efficient and accurate glucose measurement.

Main Methods:

Utilized immobilization enzyme technology and fluorescence capillary analysis.
Employed glucose oxidase (GOD) and horseradish peroxidase (HRP) for enzymatic reactions.
Developed a fluorescence reaction system involving L-tyrosine for signal generation.

Main Results:

Achieved a quantitative range of 1-10 micromol L(-1) for glucose.
Demonstrated a low detection limit of 0.62 micromol L(-1).
Exhibited high recovery rates (96-105%) and good agreement with a commercial kit.

Conclusions:

The developed biosensor is highly sensitive and accurate for glucose determination.
The biosensor shows potential for clinical application in serum glucose analysis.
This technology can aid in the diagnosis and monitoring of diabetes.