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[Changes in respiratory and peripheral muscle function in asthmatic children: effects of inhaled corticoids]

J Díaz Ledo1, R M Busquets Monge, O García-Algar

  • 1Unidad de Neumología y Alergia Pediátrica, Servicio de Pediatría, Hospital del Mar, Barcelona, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|November 27, 2009
PubMed

Insights

Inhaled corticosteroids did not impair respiratory or peripheral muscle function in children with asthma. Asthmatic children showed signs of respiratory muscle adaptation, particularly in inspiratory muscles.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Muscle Physiology
  • Pharmacological Effects in Asthma

Context:

  • Childhood asthma is a prevalent chronic condition.
  • Asthma exacerbations impose mechanical stress on respiratory muscles.
  • Inhaled corticosteroids (ICS) are a primary treatment for persistent asthma.

Purpose:

  • To assess respiratory and peripheral muscle function in children with asthma treated with ICS.
  • To investigate potential associations between muscle function and respiratory function in pediatric asthma.
  • To determine the impact of long-term ICS use on muscle status.

Summary:

  • A study compared 12 asthmatic children (on ICS for ≥2 years) with 7 healthy controls.
  • Evaluations included spirometry, lung volumes, airway resistance, muscle pressures, peripheral function, and body composition.
  • Asthmatic children exhibited air trapping and hyperinflation but similar peripheral muscle function and anthropometrics; they had higher maximum inspiratory pressures.

Impact:

  • Findings suggest ICS do not negatively affect respiratory or peripheral muscle function in pediatric asthma.
  • Evidence indicates respiratory muscle adaptation to chronic asthma-related overload.
  • This adaptation appears specific to inspiratory muscles, suggesting a localized 'training effect'.
Abstract

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