Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Asepsis01:28

Asepsis

The condition of being free from disease-causing living pathogens is asepsis. Aseptic techniques include a set of standard practices to achieve asepsis. An example is the regular environmental cleaning of all parts of the healthcare facility and hand hygiene at home before preparing or eating food. Medical and surgical asepsis in healthcare practice protects patients from harmful pathogens, minimizes the risk of contamination of susceptible sites, and reduces the risk of infection transmission.
Layers of the Heart Wall01:15

Layers of the Heart Wall

The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potassii Nitras in Chill and Fever.

Daniel's Texas medical journal·2023
Same author

Further Success with Nitre as a Remedy in Chill and Fever.

Daniel's Texas medical journal·2023
Same author

Nitrate Potassa in Chills.

Daniel's Texas medical journal·2023
Same author

Potassii Nitras in the Treatment of Chill and Fever.

Atlanta medical and surgical journal (1884)·2022
Same author

Letter from J. D. Hunter, M. D., New Orleans, La.

Atlanta medical and surgical journal (1884)·2022
Same author

Potassii Nitras in the Treatment of Chill and Fever, Clinical Notes.

Atlanta medical and surgical journal (1884)·2022
Same journal

Audit of procedural sedation complications using a novel digital application.

British journal of anaesthesia·2026
Same journal

Social deprivation and morbidity and mortality after surgery. Comment on Br J Anaesth 2025; 135: 1193-1202.

British journal of anaesthesia·2026
Same journal

Single-dose intraoperative methadone and QTc interval: a prospective observational cohort investigation.

British journal of anaesthesia·2026
Same journal

Postoperative outcomes in older patients with postoperative delirium in the UK: timing of postoperative delirium screening in the SNAP-3 study. Comment on Br J Anaesth 2026; 136: 1578-87.

British journal of anaesthesia·2026
Same journal

Population pharmacokinetic-pharmacodynamic analysis and dose optimisation of ciprofol in paediatric anaesthesia.

British journal of anaesthesia·2026
Same journal

Global environmental and geo-economic impact of conservative versus liberal oxygen strategies in mechanically ventilated critically ill adults: an ecological country-level analysis.

British journal of anaesthesia·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Sepsis and the heart.

J D Hunter1, M Doddi

  • 1Macclesfield District General Hospital, Victoria Road, Macclesfield SK10 3BL, UK. jdhunter@talk21.com

British Journal of Anaesthesia
|November 27, 2009
PubMed
Summary
This summary is machine-generated.

Septic shock causes severe heart muscle dysfunction, impacting both ventricles and reducing pumping efficiency. This review explores the causes, detection using troponin, and management strategies like levosimendan for septic cardiomyopathy.

Related Experiment Videos

Last Updated: Jun 18, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Area of Science:

  • Critical Care Medicine
  • Cardiology
  • Immunology

Background:

  • Septic shock, a severe sepsis complication, affects 10% of ICU admissions.
  • Pathophysiology involves immune stimulation, inflammation, and microvascular dysfunction.
  • Cardiovascular dysfunction includes hypovolemic, cytotoxic, and distributive shock elements.

Purpose of the Study:

  • To detail myocardial dysfunction in adult septic shock.
  • To discuss the underlying pathophysiology of septic cardiomyopathy.
  • To consider troponin's utility in detecting myocardial dysfunction.
  • To review management options for sepsis-induced left ventricular hypokinesia.

Main Methods:

  • Review of existing literature on septic shock and myocardial dysfunction.
  • Analysis of cardiovascular and myocardial changes in septic shock.
  • Evaluation of diagnostic markers like troponin.
  • Discussion of therapeutic interventions, including levosimendan.

Main Results:

  • Septic shock commonly causes significant myocardial depression (septic cardiomyopathy).
  • This is characterized by biventricular contractility impairment.
  • Left ventricular ejection fraction and stroke work index are reduced.

Conclusions:

  • Septic cardiomyopathy is a key feature of septic shock, involving biventricular dysfunction.
  • Understanding pathophysiology is crucial for effective management.
  • Troponin may aid in detection, and levosimendan is a potential therapeutic option.