Related Experiment Video
Updated: Jun 18, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Xolair is effective in allergics with a low serum IgE level
J Ankerst1, A Nopp, S G O Johansson
1Department of Medicine, Clinical Sciences, Lund, Sweden.
Background:
Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level <30 kU/l.
Methods:
Increasing dosages were given and monitored by clinical evaluation and CD-sens to clinically relevant allergens. The patients' IgE antibody fractions were 11-14%.
Results:
Xolair dosages extrapolated from a recommended dose for IgE of 30-75 kU/l were adapted to the patients' IgE body pool but had very little effect. The double dose resulted in some clinical improvement and a decrease in CD-sens. However, not until the dose was doubled again did the patients become symptom free, although 1 patient needed some additional drugs but no oral steroids. CD-sens turned negative to 5 of the 7 tested allergens.
Conclusions:
Xolair is most useful also in atopics with an IgE level <30 kU/l. The dose must be adjusted to the size of the IgE antibody fraction adding all non-cross-reacting, clinically relevant specificities.
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