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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Neurodevelopmental outcome of extremely low birth weight infants from the Vermont Oxford network: 1998-2003

Charles E Mercier1, Michael S Dunn, Karla R Ferrelli

  • 1Department of Pediatrics, University of Vermont, USA. charles.mercier@vtmednet.org

Neonatology
|November 27, 2009
PubMed

Insights

Extremely low birth weight (ELBW) infants face a high risk of severe disability, with 34% affected in this study. Outcomes varied significantly across follow-up centers, highlighting the need for more research and resources.

Area of Science:

  • Neonatal Medicine
  • Developmental Pediatrics
  • Clinical Epidemiology

Background:

  • Significant uncertainty exists in care decisions for extremely low birth weight (ELBW) infants.
  • Published outcome data often comes from specialized centers and may not represent diverse settings.
  • Accurate outcome prediction requires combining local data with published estimates.

Purpose of the Study:

  • To assess the neurodevelopmental outcomes of ELBW infants.
  • To identify factors associated with severe disability in ELBW infants.
  • To evaluate outcomes across multiple centers within the Vermont Oxford Network (VON).

Main Methods:

  • Follow-up data collected at 18-24 months corrected age for ELBW infants (401-1,000g).
  • Data gathered from 33 North American VON centers between July 1998 and December 2003.
  • Logistic regression analysis used to identify predictors of severe disability.

Main Results:

  • Of 6,198 surviving ELBW infants, 3,567 (58.4%) were evaluated at follow-up.
  • Severe disability was present in 34% of assessed infants.
  • Cystic periventricular leukomalacia, congenital malformations, and severe intraventricular hemorrhage were strongly linked to severe disability.

Conclusions:

  • ELBW infants who complete follow-up evaluations demonstrate a high risk for severe disability.
  • Significant variations in patient attrition rates were observed among participating follow-up clinics.
  • Additional resources are necessary to investigate the impact of follow-up care on ELBW infant outcomes.
Abstract

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