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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: Jun 18, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

[Glaucoma drainage devices].

H Thieme1

  • 1Augenklinik und Augenpoliklinik, Johannes Gutenberg-Universitätsmedizin, Langenbeckstr. 1, 55101, Mainz, Deutschland. thieme@augen.klinik.uni-mainz.de

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
|November 27, 2009
PubMed
Summary
This summary is machine-generated.

Glaucoma drainage devices (GDDs) create a pathway for aqueous humor to exit the eye, lowering intraocular pressure. These implants are effective for complicated glaucoma and show promise in earlier disease stages.

Related Experiment Videos

Last Updated: Jun 18, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Biomedical Engineering

Context:

  • Glaucoma drainage devices (GDDs) are established treatments for complex refractory glaucoma.
  • They are typically used when conventional surgeries have failed.

Purpose:

  • To provide an overview of the principles, indications, surgical methods, and potential complications of GDD implantation.
  • To discuss the evolving role of GDDs in glaucoma management.

Summary:

  • GDDs involve implanting a tube into the anterior chamber to drain aqueous humor.
  • The fluid collects in a subconjunctival pocket, forming a cyst that regulates outflow and reduces intraocular pressure.
  • Alternative devices target the chamber angle for drainage into Schlemm's canal or other spaces.

Impact:

  • GDDs offer a surgical solution for managing intraocular pressure in challenging glaucoma cases.
  • Recent evidence suggests their utility in earlier stages of glaucoma, expanding treatment options.
  • Understanding GDDs is crucial for ophthalmologists managing complex glaucoma patients.