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A System to Create Stable Nanoparticle Aerosols from Nanopowders
12:59

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Published on: July 26, 2016

Does electrostatic charge affect powder aerosolisation?

Handoko Adi1, Philip Chi Lip Kwok, John Crapper

  • 1Advanced Drug Delivery Group, Faculty of Pharmacy, A15, University of Sydney, Sydney, NSW 2006, Australia.

Journal of Pharmaceutical Sciences
|November 27, 2009
PubMed
Summary
This summary is machine-generated.

Electrostatic charge in mannitol powder does not significantly impact aerosol performance. Studies show similar fine particle fraction and emitted dose regardless of powder charging levels during dispersion.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Powder Technology

Background:

  • Electrostatic charge can influence powder behavior, including aerosolization.
  • Understanding charge generation mechanisms is crucial for optimizing drug delivery devices.

Purpose of the Study:

  • To investigate the role of tribocharging in mannitol powder aerosolization.
  • To determine if initial electrostatic charge affects aerosol performance metrics.

Main Methods:

  • Mannitol powder was charged by tumbling in containers of varying materials.
  • Triboelectric charging theories and contact angle measurements (gamma(-)/gamma+ ratio) were used to characterize charge.
  • Aerosol performance (fine particle fraction, emitted dose, device retention) was evaluated using an Aerolizer at different flow rates.

Main Results:

  • Powder charging correlated with container material properties (work function, gamma(-)/gamma+ ratio).
  • Despite varying charge levels, aerosol performance metrics remained consistent.
  • No significant difference in fine particle fraction, emitted dose, or device retention was observed.

Conclusions:

  • Induced electrostatic charge in mannitol powder does not significantly affect its aerosolization performance.
  • Aerosol dispersion characteristics are independent of the magnitude of charge acquired during powder handling.