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Updated: Jun 18, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Accelerated degradation of ibuprofen in tablets
Wendy Clevenger Cory1, Corbyn Harris, Sabrina Martinez
1Department of Chemistry and Biochemistry, College of Charleston, Charleston, South Carolina 29424, USA. coryw@cofc.edu
Abstract:
The forced degradation of 11 ibuprofen tablet brands was carried out according to current industry best practices. The results indicated an incompatibility between ibuprofen and two common tablet excipients (polyethylene glycol and polysorbate 80) that were observed to accelerate the degradation of ibuprofen in tablets stored for three weeks at 70°C/75% RH. Studies of binary drug/excipient samples supported the conclusion. One degradant that was observed at increased levels was 4-isobutylacetophenone (4-IBAP), which is a known toxin.
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