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Transient Middle Cerebral Artery Occlusion Model of Stroke
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Therapeutic modalities in symptomatic intracranial arterial occlusive disease

José E Cohen1, John Moshe Gomori, Felix Umansky

  • 1Department of Neurosurgery, Hebrew University-Hadassah Medical Center, Jerusalem, Israel. jcohenns@yahoo.com

Neurological Research
|November 28, 2009
PubMed

Insights

Intracranial atherosclerotic disease (ICAD) is a common cause of stroke. This review covers ICAD

Area of Science:

  • Neurology
  • Vascular Neurology
  • Cerebrovascular Disease

Background:

  • Intracranial atherosclerotic disease (ICAD) is a significant and often underdiagnosed cause of stroke.
  • Atherosclerosis affecting the intracranial arteries contributes to a substantial burden of cerebrovascular events worldwide.

Purpose of the Study:

  • To review the current literature on intracranial atherosclerotic disease (ICAD).
  • To identify key prognostic factors associated with ICAD.
  • To compare available therapeutic strategies for managing ICAD.

Main Methods:

  • Systematic literature review of studies on ICAD.
  • Analysis of prognostic indicators.
  • Comparative assessment of medical, surgical, and endovascular treatments.

Main Results:

  • ICAD is a prevalent cause of stroke, frequently missed in clinical diagnosis.
  • Prognostic factors influencing stroke risk in ICAD patients are identified.
  • Evidence comparing the efficacy and risks of different treatment modalities is presented.

Conclusions:

  • Accurate diagnosis and risk stratification are crucial for managing ICAD.
  • Treatment decisions for ICAD should be individualized based on prognostic factors and available therapeutic options.
  • Further research is needed to optimize management strategies for ICAD to reduce stroke incidence.

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