Assessment of sympathoneural activity in clinical research

The assessment of autonomic nervous activity is a frequent and challenging goal of clinical research. The diverse current approaches are reviewed. Direct recording from the sympathetic input to muscle has the advantage of excellent time resolution and directness, but gives no information on the sympathetic input to the internal organs. Plasma noradrenaline concentration has limitations of specificity, some of which are overcome by single isotope radiotracer kinetic techniques. Other chemical markers are less satisfactory. End organ responses are generally limited to cardiovascular and cutaneous autonomic assessment, but sophisticated information is obtainable using power spectral analysis of heart rate variability. Assessment of receptor systems, of first and second messengers and radionuclide imaging of adrenergic nerves all give complimentary information. It is likely that a combination of these diverse techniques will advance understanding of the role of the autonomic nervous system in many disease states.