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Related Experiment Video

Updated: Jun 18, 2026

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Dissolution parameters for sodium diclofenac-containing hypromellose matrix tablet.

Samanta C Mourão¹, Cristiane da Silva, Tania M B Bresolin

¹Núcleo de Investigações Químico-Farmacêuticas, Curso de Farmácia, Universidade do Vale do Itajaí, Rua Uruguai, 358, Centro, CEP 88302-202 Itajaí-SC, Brazil. smourao@univali.br

International Journal of Pharmaceutics

|November 28, 2009

Summary

This study developed sodium diclofenac (SD) matrix tablets and found that agitation speed significantly impacts drug release. Higher hypromellose concentrations reduced drug release, with 50 rpm identified as the most discriminatory dissolution condition.

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Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Sodium diclofenac (SD) release is crucial for dosage form efficacy.
Existing dissolution methods lack discriminatory power for SD matrix tablets.

Purpose of the Study:

Develop novel SD-containing matrix tablets.
Evaluate the impact of agitation speed on SD dissolution profiles.
Identify optimal dissolution conditions for SD matrix tablets.

Main Methods:

Formulation of three matrix tablets (F1, F2, F3) with varying hypromellose concentrations (10-30%).
Dissolution testing using USP Apparatus II in phosphate buffer (pH 6.8, 37°C) at 50, 75, and 100 rpm.
Analysis of dissolution efficiency (DE), T50, and T90 as functions of agitation speed and polymer concentration.

Main Results:

Formulation F2 exhibited higher sensitivity to agitation speed variations regarding dissolution efficiency.
Increased hypromellose concentration consistently reduced DE, irrespective of agitation.
Lower agitation speeds (50 rpm) provided the most discriminatory dissolution conditions.

Conclusions:

Agitation speed and hypromellose concentration are critical factors in SD matrix tablet dissolution.
Dissolution method development for SD matrix tablets requires careful consideration of these parameters.
The findings aid in developing robust formulations and quality control methods for SD matrix tablets.