Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Alzheimer Disease l: Introduction

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...

Disorders of Acid-Base Balance

Disorders of Acid-Base Balance

The human body maintains a precise pH range of arterial blood between 7.35 and 7.45. Deviations result in either acidosis (pH < 7.35) or alkalosis (pH > 7.45). These conditions are further classified as respiratory or metabolic disorders based on their underlying cause.
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Atrophic gastritis of the stomach: a proposal for non-invasive diagnostic algorithm.

Journal of gastrointestinal and liver diseases : JGLD·2026

Same author

Cost effectiveness of comprehensive geriatric assessment: a systematic review.

Health economics review·2026

Same author

The sound of longevity: music and technology for healthy ageing.

Aging clinical and experimental research·2026

Same author

The DICA endoscopic score and the CODA clinical score may predict the severity of acute diverticulitis and the risk of hospitalisation: results from an international multicentre prospective cohort study.

Techniques in coloproctology·2026

Same author

Hominin Variability and Evolutionary Relationships at Guattari Cave During the Middle and Late Pleistocene (San Felice Circeo, Latina, Italy).

Genes·2026

Same author

Global guidelines on diverticular disease of the colon: the Fiesole Consensus report.

Gut·2025

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Acid-related disorders in the elderly.

Marilisa Franceschi¹, Francesco Di Mario, Gioacchino Leandro

¹Endoscopy Unit, Department of Surgery, ASL Alto Vicentino, De Lellis Hospital, Via De Lellis, Schio (VI), Italy. lisa.franceschi@alice.it

Best Practice & Research. Clinical Gastroenterology

|November 28, 2009

Summary

Upper gastrointestinal diseases like GERD and peptic ulcers are more common in older adults. Prompt diagnosis and Helicobacter pylori eradication are crucial for better outcomes in the elderly.

Related Experiment Videos

Last Updated: Jun 18, 2026

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Area of Science:

Gastroenterology
Geriatric Medicine
Internal Medicine

Background:

Age-related increases in upper gastrointestinal diseases (GERD, peptic ulcer, gastric cancer) are observed.
Elderly patients often present with atypical symptoms, leading to delayed diagnosis.
Comorbidities and medications (NSAIDs, bisphosphonates) increase risks for acid-related disorders in older adults.

Purpose of the Study:

To highlight the challenges and importance of managing upper gastrointestinal diseases in the elderly.
To emphasize the role of Helicobacter pylori in gastric pathologies in older populations.
To underscore the need for effective diagnostic and therapeutic strategies.

Main Methods:

Review of age-related changes in upper gastrointestinal disease prevalence and severity.
Analysis of the impact of comorbidities and medications on elderly patients.
Evaluation of current treatment paradigms, including proton pump inhibitors and H. pylori eradication.

Main Results:

Proton pump inhibitors are foundational for symptom relief, healing, and relapse prevention.
Helicobacter pylori infection is highly prevalent in the elderly and linked to gastric lesions, precancerous conditions, and cancer.
Delayed diagnosis due to atypical presentations is a significant issue in older patients.

Conclusions:

Effective management of upper gastrointestinal diseases in the elderly requires timely diagnosis and treatment.
Eradication of H. pylori is paramount for preventing severe gastric conditions in older individuals.
Improved strategies can reduce mortality and enhance the quality of life for elderly patients with these disorders.