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Genetic predisposition of E-selectin gene (S128R) polymorphism in patients with coronary artery disease (CAD)

Rajneesh Tripathi1, Prabhat Kumar Singh, Satyendra Tewari

  • 1Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

The Indian Journal of Medical Research
|November 28, 2009
PubMed

Insights

The E-selectin gene S128R polymorphism showed a univariate association with coronary artery disease (CAD). However, it was not an independent predictor, with diabetes, hypertension, and smoking being significant determinants of CAD.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • E-selectin, a surface glycoprotein, mediates leukocyte adhesion to endothelium, playing a role in atherosclerosis pathogenesis.
  • The S128R polymorphism in the E-selectin gene is investigated for its potential association with coronary artery disease (CAD).

Purpose of the Study:

  • To investigate the association of the E-selectin gene S128R polymorphism with angiographically proven coronary artery disease (CAD) in a North Indian population.
  • To identify independent predictors of CAD in the study cohort.

Main Methods:

  • Genotyping of the E-selectin S128R polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • The study included 329 CAD patients (including acute myocardial infarction cases) and 331 controls, all angiographically assessed.

Main Results:

  • Univariate analysis indicated a significant association between the R allele and CAD (allele frequency 9.6% in patients vs. 5.6% in controls, P=0.031).
  • Binomial logistic regression identified diabetes, hypertension, smoking, elevated triglycerides, and low HDL-C as significant independent determinants of CAD.
  • The E-selectin S128R polymorphism did not emerge as an independent predictor of CAD after multivariate analysis.

Conclusions:

  • Classical risk factors such as diabetes, hypertension, smoking, elevated serum triglycerides, and low HDL-C are significant determinants of coronary artery disease in this population.
  • The S128R polymorphism in the E-selectin gene is not an independent predictor of CAD in the studied population.
Abstract

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