Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Management of anticoagulants in ophthalmic surgery-a survey among ophthalmic surgeons in Germany].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2018
Same author

[Oral anticoagulation : Current overview and perioperative management in ophthalmic surgery].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·2018
Same author

Electronic alert system for improving appropriate thromboprophylaxis in hospitalized medical patients: a randomized controlled trial.

Journal of thrombosis and haemostasis : JTH·2017
Same author

Early pulmonary arterial hypertension immediately after closure of a ventricular or complete atrioventricular septal defect beyond 6months of age.

International journal of cardiology·2016
Same author

Survival and cardiovascular events after coarctation-repair in long-term follow-up (COAFU): Predictive value of clinical variables.

International journal of cardiology·2016
Same author

[Clinical classification and initial diagnosis of pulmonary hypertension: recommendations of the Cologne Consensus Conference 2016].

Deutsche medizinische Wochenschrift (1946)·2016

Related Experiment Video

Updated: Jun 18, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
09:24

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

Hypertension in aortic coarctation.

A Hager1

  • 1Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, Germany. a-hager@web.de

Minerva Cardioangiologica
|November 28, 2009
PubMed
Summary
This summary is machine-generated.

Patients with aortic coarctation often develop hypertension through distinct pathways. Understanding these, including re-stenosis, paradoxical, and late hypertension, is crucial for effective patient treatment and improved outcomes.

More Related Videos

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
10:18

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Published on: June 29, 2014

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice
08:10

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Published on: April 5, 2018

Related Experiment Videos

Last Updated: Jun 18, 2026

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy
09:24

O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

Published on: October 6, 2022

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
10:18

Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model

Published on: June 29, 2014

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice
08:10

A Closed-chest Model to Induce Transverse Aortic Constriction in Mice

Published on: April 5, 2018

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Hypertension Research

Background:

  • Aortic coarctation (CoA) is a congenital heart defect associated with significant long-term cardiovascular risks.
  • Arterial hypertension is a common and serious complication in patients with repaired or unrepaired CoA.
  • Hypertension-related complications are a leading cause of mortality in the CoA population.

Purpose of the Study:

  • To review and synthesize current knowledge on the different pathophysiologic pathways of hypertension in aortic coarctation patients.
  • To provide guidance on differentiating these distinct hypertensive pathways.
  • To outline appropriate treatment strategies for each identified pathway.

Main Methods:

  • Systematic review of existing literature on aortic coarctation and associated hypertension.
  • Analysis of pathophysiologic mechanisms underlying re-stenosis, paradoxical hypertension, and late-onset hypertension.
  • Evaluation of diagnostic criteria and clinical approaches for differentiating hypertensive pathways.
  • Summary of current evidence-based treatment guidelines.

Main Results:

  • Identified three primary pathophysiologic pathways leading to hypertension in CoA patients: aortic isthmus re-stenosis, paradoxical hypertension, and late hypertension.
  • Highlighted key clinical and diagnostic features that distinguish each pathway.
  • Emphasized the direct link between hypertension and mortality in this patient cohort.

Conclusions:

  • Accurate differentiation of hypertensive pathways in aortic coarctation is essential for tailoring treatment.
  • Targeted management strategies based on the specific pathway can optimize clinical outcomes.
  • Further research is needed to refine diagnostic and therapeutic approaches for hypertensive CoA patients.