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Related Experiment Video

Updated: Jun 18, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Soy sauce allergy.

K Sugiura¹, M Sugiura

¹Department of Environmental Dermatology and Allergology, Daiichi Clinic, Nakaku, Nagoya, Japan. ksugiura@daiichiclinic.jp

Journal of the European Academy of Dermatology and Venereology : JEADV

|December 1, 2009

Summary

Rare soy sauce allergies can cause mouth inflammation. This study identified histamine in soy sauce as a cause, distinct from soy or wheat allergies, aiding in diagnosis.

Area of Science:

Food Science
Allergology
Clinical Immunology

Background:

Soy sauce (shoyu) is a common Japanese seasoning with known benefits and adverse effects.
While soy sauce allergies are rare, this study focuses on cases not caused by soy or wheat allergies.
Adverse reactions to soy sauce can manifest as dermatitis and cellulitis around the mouth.

Purpose of the Study:

To investigate the causes of rare soy sauce-induced oral inflammations.
To differentiate between allergic reactions and histamine poisoning as causes of these symptoms.
To identify specific components in soy sauce responsible for adverse reactions.

Main Methods:

Analysis of histamine content in various soy sauces.
Performing skin prick tests on affected patients and healthy volunteers.

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Conducting laboratory tests, including specific IgE scoring for soy and wheat.

Main Results:

Four patients presented with positive skin prick test reactions to certain soy sauces.
Histamine was detected in soy sauce made from soybean and broad bean, correlating with patient symptoms.
Patients showed no allergic reaction to soy or wheat (IgE class 0), indicating a non-soy/wheat allergy cause.

Conclusions:

Confirmed four cases of soy sauce allergy attributed to brewing byproducts, distinct from soy or wheat allergies.
Highlights the importance of considering histamine poisoning alongside allergic reactions in patients with oral inflammation after soy sauce consumption.
Recommends diagnostic evaluation for both allergic reactions and histamine content in suspected soy sauce-induced dermatitis or cellulitis.