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Related Experiment Videos

Age and indications to SLIT.

L Terracciano1, E Calcinai, S Avitabile

  • 1SS Asma e Malattie Polmonari, UO Pediatria, Presidio Ospedaliero Macedonio Melloni, Azienda Ospedaliera Fatebenefratelli ed Oftalmico, Milano.

International Journal of Immunopathology and Pharmacology
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Sublingual immunotherapy (SLIT) shows clinical efficacy in children with allergic asthma and rhinitis, potentially preventing new allergies and asthma. However, definitive recommendations are pending further evidence, with a suggested minimum age of 5 years.

Area of Science:

  • Pediatric Allergy and Immunology
  • Immunotherapy Research
  • Clinical Evidence Synthesis

Background:

  • Sublingual immunotherapy (SLIT) has been studied for two decades.
  • Meta-analyses indicate SLIT's efficacy in pediatric allergic asthma and rhinitis.
  • Current evidence limits strict treatment recommendations.

Purpose of the Study:

  • To review the clinical efficacy and safety of SLIT in children.
  • To evaluate SLIT's role in preventing new sensitizations and asthma.
  • To assess the current evidence for SLIT in various allergic conditions.

Main Methods:

  • Systematic review of meta-analyses and clinical studies on SLIT in children.
  • Analysis of data regarding efficacy in allergic asthma, rhinitis, atopic dermatitis, and food allergies.

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  • Evaluation of safety data and age limitations for SLIT initiation.

    • Main Results:

    • SLIT demonstrates clinical efficacy in children with allergic rhinitis and asthma.
    • Evidence suggests SLIT can prevent new allergic sensitizations and the development of asthma.
    • Studies on SLIT for asthma in children show discordant results, potentially due to symptom triggers.
    • Emerging data on SLIT for atopic dermatitis, food, and latex allergies exist but require more research.
    • SLIT is considered safe in children as young as 3 years, though 5 years is often cited as a minimum.

    Conclusions:

    • SLIT is effective for pediatric allergic rhinitis and asthma, with preventive benefits.
    • Discordant results in asthma studies necessitate further investigation into allergic vs. non-allergic triggers.
    • SLIT for atopic dermatitis, food, and latex allergies is still in the research phase.
    • While safe from age 3, current evidence supports SLIT recommendations primarily for children aged 5 and above.